Drug intelligence / Profile preview

Adhexil

Development stage
Phase 3
Lead developer
Johnson & Johnson
Modality
Blood Coagulation Factors → Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration
Topical
01

Overview

**Adhexil** was an investigational, human fibrin-based surgical adhesion-prevention kit developed by Omrix Biopharmaceuticals for use after gynecologic surgery involving the ovaries. The product supplied separate sterile human thrombin and fibrinogen-containing biologically active component solutions with a laparoscopic applicator; upon application, thrombin converts fibrinogen to a stable fibrin clot that forms a smooth, absorbable physical barrier over injured tissue surfaces, intended to reduce postoperative adhesion formation. It was studied in randomized Phase I/II and later pivotal Phase III gynecologic-surgery programs. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00544310))

Brand names
Adhexil
Other names
Omrix Anti-Adhesion agent
02

Targets

PLG (Plasminogen)

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