Drug intelligence / Profile preview

ADI-212

Development stage
Phase 2
Lead developer
Adicet Bio
Modality
CRISPR-Cas12 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, CRISPR-Cas13 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Cytosine Base Editors → Base Editing → Gene Editing → Gene Therapies, TALENs → Other Nucleases → Programmable Nucleases → Gene Editing → Gene Therapies, Standard Prime Editors → Prime Editing → Gene Editing → Gene Therapies, Zinc Finger Nucleases → Other Nucleases → Programmable Nucleases → Gene Editing → Gene Therapies, Adenine Base Editors → Base Editing → Gene Editing → Gene Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Enhanced Prime Editors → Prime Editing → Gene Editing → Gene Therapies
Administration
Intravenous
01

Overview

ADI-212 is an optimized next-generation, gene-edited and cytokine-armored allogeneic gamma delta CAR T-cell therapy candidate targeting the prostate specific membrane antigen for solid tumors. According to Adicet’s July 2025 disclosure, ADI-212 is designed to enhance potency in solid tumors and to deliver additional anti-tumor mechanisms within the tumor microenvironment; in IND-enabling studies it showed improved potency and tumor-cell killing compared with prior alpha-beta and gamma delta CAR T oncology programs. The company prioritized ADI-212 alongside ADI-001 and discontinued ADI-270, positioning ADI-212 as a successor program that builds on exposure/expansion observed clinically with ADI-270.[3][7]

Other names
allogeneic CAR gamma delta T cell therapy targeting PSMAPSMA-targeting CAR gamma delta T cell therapy

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