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Drug intelligence / Profile preview
AdIL-1β
- Development stage
- Unknown
- Modality
- Gene Therapies
- Administration
- Inhalation, Intraarticular, Intralesional, Intraperitoneal, Intravenous
01
Overview
AdIL-1β is a replication-deficient adenoviral vector (typically adenovirus serotype 5) engineered to express human or rodent interleukin-1 beta (IL-1β). Developed as a preclinical research tool, AdIL-1β is widely used to transiently or chronically overexpress the pro-inflammatory cytokine IL-1β in vivo. This vector is utilized to establish animal models of chronic inflammatory and autoimmune diseases, including chronic active cortical lesions (modeling multiple sclerosis), rheumatoid arthritis, peritoneal fibrosis, and airway remodeling. Additionally, AdIL-1β has been investigated in preclinical studies as a genetic adjuvant to enhance mucosal and systemic immune responses in viral vaccine candidates.
- Other names
- Ad-IL-1betaAd-IL1betaAd-IL 1betaAd-IL-1βAdIL-1betaAdIL1betaAdIL 1betaadenovector expressing interleukin-1 betaadenovirus expressing IL-1betaadenovirus expressing IL-1βadenovirus expressing interleukin-1 beta
02
Targets
CXADR (Coxsackievirus and adenovirus receptor)
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