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adipocyte-derived stem cell conditioned media
- Development stage
- Unknown
- Lead developer
- Kimia Farma
- Modality
- Cell Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical, Intradermal
01
Overview
Adipocyte-derived stem cell conditioned media is a **cell-free mixture of bioactive factors** secreted by adipose (fat) tissue-derived stem cells, collected from their culture medium after a period of growth. It contains a cocktail of **growth factors, cytokines, exosomes, and signaling molecules** including VEGF, IL-6, HGF, TGF-β1, and various mRNAs and noncoding RNAs, supporting **cell growth, proliferation, wound healing, regeneration, and immunomodulation**[1][2][3][4][5][9]. These secreted factors promote tissue repair via **paracrine mechanisms**, modulating inflammation, enhancing migration and proliferation of dermal fibroblasts, increasing collagen production, and facilitating wound and tissue healing[2][5][9]. The product is being studied for use in **regenerative medicine, wound care, hair regeneration, and tissue engineering**. It is cell-free, theoretically reducing the risks and complexities associated with cell-based therapies[2][4][6][9]. There is currently no single pharmaceutical product by this name; it is used as a research and investigational regenerative therapy.
- Other names
- human adipose-derived stem cell conditioned mediaADSC-conditioned mediaADSC-CMASC-CMadipose-derived mesenchymal stem cell conditioned media
02
Targets
EGFR (Epidermal growth factor receptor)IL-6R (Interleukin-6 receptor subunit alpha)NTRK1 (Tropomyosin-related receptor kinase A)MET (Mesenchymal-epithelial transition factor receptor)
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