adjusted xiaoyaosan decoction

Adjusted xiaoyaosan decoction (also known as Jiawei Xiaoyaosan or Danzhi Xiaoyaosan) is a traditional Chinese medicine (TCM) herbal formula widely used for the treatment of psychological stress-related disorders, including insomnia, anxiety, and depression. It is a modified version of the classic Xiaoyaosan formula, typically prepared by adding Moutan Cortex (Danpi) and Gardeniae Fructus (Zhizi) to clear heat and soothe the liver. The decoction is thought to exert its therapeutic effects by regulating the hypothalamic-pituitary-adrenal (HPA) axis, modulating central neurotransmitters such as dopamine, serotonin, and norepinephrine, and reducing neuroinflammation. It has been evaluated in clinical trials, including a Phase IV study by The Second Hospital Affiliated to Guangzhou University of TCM, both as a monotherapy and in combination with sedative-hypnotics like estazolam (surazepam) for patients with psychological stress-related psychophysiological insomnia.

Other names

Danzhi Xiaoyao SanDanzhi XiaoyaosanDanzhi Xiaoyaosan decoctionJiawei Xiaoyao SanJiawei XiaoyaosanJiawei Xiaoyaosan decoctionadjusted Xiaoyaosanadjusted Xiaoyaosan decoctionmodified Xiaoyaosanmodified Xiaoyaosan decoction丹栀逍遥散加味逍遥散