Ado-P-Ch2-P-Ps-Ado

Ado-P-Ch2-P-Ps-Ado is a synthetic small molecule and an experimental analog of dinucleoside polyphosphates. Structurally, it is a modified diadenosine triphosphate in which the central phosphate bridge contains a methylene group (CH₂) and one terminal phosphate is replaced by a thiophosphate (Ps). It has been studied primarily as a biochemical probe for enzymes with dinucleoside triphosphate hydrolase activity, such as those that cleave P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap₃A), yielding AMP and ADP. The compound can also be hydrolyzed by adenylylsulfatase activity to yield AMP and sulfate, or act as an adenosine 5'-monophosphoramidase substrate. Its main use is in enzymology research rather than clinical medicine[1][4][6].

Other names

P1-P2-methylene-P3-thio-diadenosine triphosphateP-1-P2-methylene-P3-thio-diadenosine triphosphateP 1-P2-methylene-P3-thio-diadenosine triphosphate