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Drug intelligence / Profile preview
AdOral Sema is an orally administered formulation of semaglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist. Developed by Adocia, this product leverages the proprietary AdOral technology to enhance the oral bioavailability of semaglutide, which is typically administered via injection. Preclinical studies indicate that the absorption and bioavailability of semaglutide are significantly improved with this formulation compared to existing oral options such as Rybelsus. Semaglutide itself is approved for type 2 diabetes management, weight loss, and weight maintenance due to its ability to reduce appetite, delay gastric emptying, increase insulin release in response to meals, and lower glucagon secretion[10][3][4].
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