Drug intelligence / Profile preview

ADSCs-Exo + Sflt-1

Development stage: Preclinical
Modality: Gene Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

ADSCs-Exo + Sflt-1 is an experimental, preclinical gene-loaded exosome biologic designed to treat rheumatoid arthritis-associated interstitial lung disease (RA-ILD). It consists of exosomes derived from adipose-derived stem cells (ADSCs) engineered to deliver the soluble vascular endothelial growth factor receptor 1 (Sflt-1) gene. Sflt-1 acts as a decoy receptor that binds to and antagonizes vascular endothelial growth factor (VEGF), thereby inhibiting VEGF-mediated angiogenesis and inflammation. In preclinical mouse models, this therapy has demonstrated the ability to alleviate both joint inflammation and pulmonary fibrosis/inflammation by reducing pro-inflammatory cytokines (IL-1β, IL-6, IL-17A) and pro-fibrotic factors (TGF-β, VCAM).

Other names: adipose-derived stem cell-derived exosomes packaging Sflt-1mesenchymal stem cell-derived exosomes packaging Sflt-1

Targets

VEGFB (Vascular endothelial growth factor B)PGF (Placental Growth Factor)VEGFA (Vascular endothelial growth factor A)

Beyond the preview

Go deeper on ADSCs-Exo + Sflt-1.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ADSCs-Exo + Sflt-1.

Explore the full profile