Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
AdSmCB
- Development stage
- Preclinical
- Lead developer
- Research Institute of the McGill University Health Centre
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
AdSmCB is a recombinant human adenovirus serotype 5 (HAdV-5) viral vector vaccine expressing *Schistosoma mansoni* cathepsin B (SmCB), a parasitic gut peptidase essential for helminth growth and maturation. Developed by researchers at the Research Institute of the McGill University Health Centre and the National Research Council Canada, AdSmCB is designed as a prophylactic vaccine for intestinal schistosomiasis. In preclinical models, intramuscular administration of AdSmCB followed by recombinant protein boosts (such as SmCB adjuvanted with AddaVax) elicits robust humoral and cell-mediated immune responses, including antigen-specific IgG1, IgG2c, serum IgA, and Th1/Th2 cytokines, leading to a significant reduction in parasite burden and associated liver pathology.
- Other names
- AdV-SmCBrecombinant adenovirus expressing Schistosoma mansoni cathepsin B
Beyond the preview
Go deeper on AdSmCB.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on AdSmCB.