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adsorbed acellular diphtheria, tetanus, pertussis, inactivated poliovirus, and Haemophilus influenzae type b pentavalent combined vaccine
- Development stage
- Unknown
- Lead developer
- Shenzhen Kangtai Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The adsorbed acellular diphtheria, tetanus, pertussis, inactivated poliovirus, and Haemophilus influenzae type b pentavalent combined vaccine is a multi-antigen biologic developed by **Shenzhen Kangtai Biological Products Co., Ltd. (Biokangtai)**. This pediatric combination vaccine is designed to provide simultaneous protection against five major infectious diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, and invasive disease caused by *Haemophilus influenzae* type b (Hib). The formulation utilizes acellular pertussis antigens (rather than whole-cell components) and inactivated poliovirus (IPV) types 1, 2, and 3, alongside diphtheria and tetanus toxoids and a Hib conjugate, all adsorbed onto an aluminum-based adjuvant to enhance immunogenicity. By combining these five components into a single injection, the vaccine aims to simplify the immunization schedule for infants and young children, improving compliance and reducing the number of required clinical visits. It is currently in Phase 2 clinical development in China, with reports indicating it is approaching Phase 3.
- Other names
- DTaP-IPV-Hib vaccineBiokangtai pentavalent vaccineAdsorbed acellular DTP-IPV-Hib pentavalent combined vaccine
02
Targets
Diphtheria toxinFHA (Filamentous hemagglutinin)Pertactin / fimbrial pertussis surface antigens
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