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ADVAX

Development stage
Phase 1
Lead developer
Aaron Diamond AIDS Research Center
Modality
DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**ADVAX** is an investigational multigenic **DNA plasmid preventive HIV-1 vaccine** developed from a clade C/B' circulating recombinant form of HIV-1 prevalent in Yunnan, China. The product is a 1:1 mixture of two pVAX-derived plasmids encoding HIV-1 **Env, Gag, Pol, Nef, and Tat** antigens. It is intended to induce HIV-specific cellular and humoral immune responses and was evaluated in healthy HIV-uninfected adults in Phase 1 studies, including intramuscular administration and intramuscular administration with in vivo electroporation. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20111582/))

Other names
ADVAX DNA HIV vaccineADVAX e/g + ADVAX p/n-t
02

Targets

HIV-1 Pol polyproteinTat (HIV-1 Tat)Nef (HIV-1 Nef)Gag (HIV-1 Gag polyprotein)

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