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AdVhAFP
- Development stage
- Phase 1
- Lead developer
- University of Pittsburgh
- Modality
- Vaccines & Immunotherapeutics, Gene Silencing → Gene Therapies, Gene Editing → Gene Therapies, Gene Addition/Replacement → Gene Therapies
- Administration
- Intradermal, Subcutaneous, Ex Vivo
01
Overview
AdVhAFP is a recombinant, replication-deficient adenoviral vector engineered to express the human alpha-fetoprotein (AFP) gene. It is designed as an immunotherapy for hepatocellular carcinoma (HCC), a malignancy that frequently overexpresses AFP as a tumor-associated antigen. The vector is primarily used to transduce dendritic cells (DCs) ex vivo or administered directly to induce and expand AFP-specific CD4+ helper and CD8+ cytotoxic T-cell responses. By utilizing an adenoviral delivery system, the therapy aims to overcome immunological tolerance to AFP, which is a self-antigen, thereby promoting a robust Th1-skewed immune response capable of recognizing and eliminating AFP-positive tumor cells.
- Other names
- AFP-expressing adenovirusAdenovirus-hAFPhAFP-adenovirus
02
Targets
AFP (Alpha-fetoprotein)
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