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ADx-001
- Development stage
- Unknown
- Lead developer
- Alzeca Biosciences
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
ADx-001 is a targeted liposomal MRI contrast agent developed by Alzeca Biosciences for the early diagnosis of Alzheimer's disease. The agent consists of liposomes containing gadolinium-DOTA (Gd-DOTA) chelates, which are engineered to cross the blood-brain barrier and specifically bind to amyloid-beta (Aβ) plaques in the brain. By concentrating gadolinium at the site of these plaques, ADx-001 enhances the MRI signal, allowing for the non-invasive visualization of amyloid pathology. This technology is intended to provide a more widely available and cost-effective diagnostic tool compared to amyloid PET imaging, potentially facilitating earlier intervention and better monitoring of disease progression.
- Brand names
- ADx-001ADx001ADx 001
- Other names
- DSPE-DOTA-Gd liposomalTargeted liposomal MRI contrast agentAlzeca MRI contrast agent
02
Targets
Aβ (Amyloid-beta peptides and aggregates)
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