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ADX-914-XL

Development stage: Preclinical
Lead developer: Q32 Bio
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Parenteral, Subcutaneous

Overview

ADX-914-XL is a fully human, half-life-extended monoclonal antibody in preclinical development by Q32 Bio. It is designed as a biobetter of bempikibart (ADX-914) to target and inhibit the interleukin-7 receptor alpha subunit (IL-7Rα). By blocking IL-7Rα, ADX-914-XL dual-inhibits signaling mediated by both interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), which are key drivers of T cell-mediated pathological processes in various autoimmune and inflammatory diseases. Developed using half-life extension technology, ADX-914-XL aims to provide the same clinical activity and safety profile as bempikibart while offering a more convenient, extended dosing schedule.

Other names: ADX 914 XLADX914 XLADX-914 XLhalf-life extended ADX-914half-life extended bempikibarthalf-life-extended ADX-914half-life-extended bempikibart

Targets

IL7R (Interleukin-7 Receptor)

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