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ADX-MAPT

Development stage: Preclinical
Lead developer: ADARx Pharmaceuticals
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intrathecal

Overview

ADX-MAPT is an investigational small interfering RNA (siRNA) therapeutic targeting the microtubule-associated protein tau (MAPT), also known as TAU. It is designed to inhibit the expression of tau protein, which plays a key role in neurodegenerative diseases such as Alzheimer's disease. By inhibiting tau, ADX-MAPT aims to reduce pathological tau accumulation and its associated neurotoxicity. The drug is being developed by ADARx Pharmaceuticals and is currently at the discovery stage for the treatment of Alzheimer's disease[1].

Targets

MAPT (Microtubule-associated protein tau)

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