Drug intelligence / Profile preview

aegle marmelos leaf extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Aegle marmelos leaf extract is a botanical preparation derived from the leaves of *Aegle marmelos*, a medicinal plant used in traditional medicine. In the provided preclinical literature, it was studied as an orally administered plant extract for cognitive impairment in a scopolamine-induced rat model of Alzheimer's disease, where it showed dose-dependent improvement in memory-related outcomes and preservation of hippocampal synaptophysin and dendritic spine density. Its putative mechanism is not fully defined, but the cited study and background suggest acetylcholinesterase inhibitory activity together with broader neuroprotective effects on synaptic integrity. It is best characterized as an investigational botanical extract or nutraceutical-style natural product rather than a conventional single-agent pharmaceutical drug with a standardized developer-led clinical program.

Other names
Aegle marmelos leaf extractbael leaf extractAM leaf extract
02

Targets

mAChR (Muscarinic acetylcholine receptors)5-HT (Serotonin receptors)Acetylcholinesterase

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