AEOL 20415

AEOL 20415 is a **small molecule** metalloporphyrin-based catalytic antioxidant designed to neutralize reactive oxygen and nitrogen species, reducing oxidative stress, inflammation, and tissue damage. Developed initially by Aeolus Pharmaceuticals, it has shown efficacy in preclinical animal models of **cystic fibrosis**, protecting lungs from infection, improving clinical scores of lung health, increasing blood oxygen saturation, and decreasing airway casts and pro-inflammatory cytokines like TNF-α, IL-6, and TGF-β1. It also demonstrates broad-spectrum antimicrobial activity against antibiotic-resistant bacteria and potential against chemical warfare agents such as sulfur mustard gas, with applications in infectious diseases and resistant pathogens.[1][2][3][5][7]

Other names

AEOL-20415AEOL20415AEOL 20415