AER-271

AER-271 is a phosphonate prodrug of AER-270 and acts as a selective inhibitor of aquaporin-4 (AQP4) water channels. It is designed to reduce cerebral edema by blocking the movement of water into the central nervous system under ischemic conditions. After administration, AER-271 is converted in vivo to its active form (AER-270) by endogenous phosphatases. The drug has shown efficacy in preclinical models for reducing brain swelling and improving neurological outcomes following acute ischemic stroke and other CNS injuries associated with edema. It is being developed primarily for the treatment of cerebral edema after acute severe ischemic stroke[1][2][3][4][8].

Other names

aer-270aer270aer 270