Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
aescin + micronized purified flavonoid fraction
- Development stage
- Unknown
- Lead developer
- Chiang Mai University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination therapy consists of aescin, a saponin mixture derived from horse chestnut (*Aesculus hippocastanum*), and micronized purified flavonoid fraction (MPFF), which typically contains 90% diosmin and 10% other flavonoids such as hesperidin. The combination is being evaluated in a randomized controlled trial led by Chiang Mai University for the early control of bleeding and symptom management in patients with grade 1 and 2 acute internal hemorrhoids. Aescin provides anti-edematous, anti-inflammatory, and venotonic properties by facilitating ion entry into channels and elevating venous tension. MPFF complements these effects by augmenting venous tone, reducing capillary hyperpermeability, and inhibiting inflammatory mediators, thereby addressing the stagnation of blood and subsequent inflammatory response characteristic of hemorrhoidal disease.
- Other names
- aescin + MPFFhorse chestnut extract + micronized purified flavonoid fraction
02
Targets
PGE2 (Prostaglandin E2)TXA2 (Thromboxane A2)
Beyond the preview
Go deeper on aescin + micronized purified flavonoid fraction.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on aescin + micronized purified flavonoid fraction.