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AET-1978
- Development stage
- Preclinical
- Lead developer
- Methodist Hospital Research Institute
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Subcutaneous
01
Overview
AET-1978 is a patent-pending, custom-designed bone morphogenetic protein-7 (BMP-7) mRNA formulated in lipid nanoparticles (LNPs). Developed by researchers at the Houston Methodist Research Institute, AET-1978 is designed to suppress endothelial-to-mesenchymal transition (EndoMT) and attenuate cardiac fibrosis. In preclinical models of non-ischemic heart failure, subcutaneous administration of AET-1978 significantly improved left ventricular systolic and diastolic function, reduced myocardial fibrosis, and preserved endothelial phenotype and function without causing systemic toxicity. This transient, non-integrating mRNA therapeutic platform represents a novel approach to targeting residual fibrotic pathways in heart failure.
- Other names
- BMP-7 mRNA lipid nanoparticlesBMP7 mRNA lipid nanoparticlesBMP 7 mRNA lipid nanoparticlesBMP-7 mRNA-LNPBMP7 mRNA-LNPBMP 7 mRNA-LNPBone morphogenetic protein-7 mRNA lipid nanoparticles
02
Targets
BMP (Bone morphogenetic protein family)
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