Drug intelligence / Profile preview

AF165

Development stage: Preclinical
Lead developer: German Cancer Research Center
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Subcutaneous

Overview

AF165 is a human recombinant monoclonal antibody targeting bone sialoprotein (BSP), developed by Immundiagnostik AG and the German Cancer Research Center (DKFZ). Bone sialoprotein is a glycoprotein highly expressed in bone-metastatic malignancies, including breast cancer, where it is associated with tumor progression and skeletal metastasis. AF165 binds to BSP and has demonstrated preclinical efficacy in vivo, inducing dose-dependent remissions in rat models of breast cancer skeletal metastasis. To improve its cellular uptake and cytotoxic properties, AF165 has also been fused to cell-penetrating peptides (CPPs) such as TAT and Pep1, which show enhanced affinity and induce apoptosis in breast cancer cells in vitro.

Other names: AF165 (a-BSP)anti-BSP antibody AF165human recombinant anti-BSP antibody AF165

Targets

BSP (Bone sialoprotein)

Beyond the preview

Go deeper on AF165.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on AF165.

Explore the full profile