Drug intelligence / Profile preview

afatinib + pemetrexed + gemcitabine + cisplatin + carboplatin

Development stage
Unknown
Lead developer
Boehringer Ingelheim
Modality
Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

This combination therapy consisting of afatinib, pemetrexed, gemcitabine, cisplatin, and carboplatin is not identified as a known or studied single treatment regimen based on available search results. The search results primarily discuss various combinations of these drugs, most notably a phase I study investigating the combination of afatinib, carboplatin, and pemetrexed for EGFR-mutated non-small cell lung cancer (NSCLC) patients who progressed during treatment with first-generation EGFR tyrosine kinase inhibitors (TKIs). Other combinations involving subsets of these drugs (e.g., afatinib with carboplatin, cisplatin plus pemetrexed, gefitinib with pemetrexed and carboplatin) have been studied, but not the specific five-drug combination requested.

02

Targets

DNADHFR (Dihydrofolate reductase)EGFR (Epidermal growth factor receptor)GART (GAR transformylase)ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)RNR (Ribonucleotide reductase)TS (Thymidylate synthase)

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