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afatinib + vinorelbine
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Afatinib (BIBW 2992) is an oral, irreversible inhibitor of the ErbB family of tyrosine kinases, including epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2), and to a lesser extent HER4 (ErbB4). It blocks signaling pathways involved in the proliferation and survival of cancer cells. Vinorelbine is a semi-synthetic vinca alkaloid that inhibits microtubule assembly, thereby disrupting mitosis and leading to cell death. The combination has been investigated for use in advanced solid tumors, particularly HER2-overexpressing breast cancer and non-small cell lung cancer. Afatinib was developed by Boehringer Ingelheim[1][4][5][6][8].
- Brand names
- Giotrif
- Other names
- afatinib + vinorelbine
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)TUBB (Tubulin (alpha and beta subunits))ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)
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