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Afiveg is a biosimilar biological medicine developed by STADA Arzneimittel AG, containing the active substance aflibercept. It is a recombinant fusion protein that functions as a soluble decoy receptor, binding to and neutralizing vascular endothelial growth factor A (VEGF-A) and placental growth factor (PlGF). By inhibiting these growth factors, Afiveg prevents the abnormal proliferation of blood vessels and reduces vascular leakage in the eye, which are key drivers of several retinal diseases. The drug is indicated for the treatment of adults with neovascular (wet) age-related macular degeneration (AMD), visual impairment due to macular edema secondary to retinal vein occlusion (RVO), diabetic macular edema (DME), and myopic choroidal neovascularization (mCNV). It is administered via intravitreal injection and was granted marketing authorization in the European Union in August 2025.
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