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aflibercept + docetaxel
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Aflibercept + docetaxel is a combination therapy consisting of aflibercept, a recombinant human fusion protein that acts as a decoy receptor for vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PlGF), and docetaxel, a cytotoxic taxane chemotherapy agent. Aflibercept inhibits angiogenesis by binding to VEGF-A, VEGF-B, and PlGF with high affinity, preventing their interaction with native receptors on the surface of endothelial cells. Docetaxel promotes microtubule assembly while inhibiting disassembly, leading to cell cycle arrest and apoptosis in rapidly dividing tumor cells. This combination has been investigated primarily in advanced solid tumors such as metastatic castrate-resistant prostate cancer and other advanced malignancies[1][2][4][5].
02
Targets
PGF (Placental Growth Factor)VEGFB (Vascular endothelial growth factor B)VEGFA (Vascular endothelial growth factor A)TUBB (Tubulin (alpha and beta subunits))
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