Drug intelligence / Profile preview

AFX-718

Development stage: Preclinical
Lead developer: Afecta Pharmaceuticals
Modality: Small Molecules

Overview

AFX-718 is a small molecule therapeutic candidate being developed by Afecta Pharmaceuticals for the treatment of inflammatory ocular conditions, specifically uveitis and scleritis. The drug's mechanism of action involves the modulation of multiple T-cell activation pathways to restore the homeostatic balance between pro-inflammatory T helper (Th) cells and immunosuppressive regulatory T (Treg) cells. By influencing this Th/Treg balance, AFX-718 aims to suppress the excessive immune response and intraocular inflammation characteristic of these diseases. As of the latest pipeline updates, AFX-718 is in late-stage preclinical development.

Beyond the preview

Go deeper on AFX-718.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on AFX-718.

Explore the full profile