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AG + FOLFIRINOX
- Development stage
- Phase 2
- Lead developer
- Tianjin Medical University Cancer Institute and Hospital
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
AG + FOLFIRINOX is a sequential chemotherapy regimen being investigated as a neoadjuvant and adjuvant treatment for patients with resectable pancreatic cancer. The regimen consists of two distinct phases: the AG regimen, which combines nab-paclitaxel (albumin-bound paclitaxel) and gemcitabine, followed by the FOLFIRINOX regimen, which includes oxaliplatin, irinotecan, leucovorin (folinic acid), and 5-fluorouracil (5-FU). This sequential approach is designed to utilize multiple cytotoxic mechanisms—including microtubule stabilization, DNA synthesis inhibition, DNA cross-linking, and topoisomerase I inhibition—to maximize therapeutic efficacy and improve surgical outcomes in pancreatic adenocarcinoma. The regimen is currently being evaluated in a Phase II clinical trial sponsored by the Tianjin Medical University Cancer Institute and Hospital.
- Other names
- AG followed by FOLFIRINOXSequential AG and FOLFIRINOX
02
Targets
DNATOP1 (DNA Topoisomerase I)TS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))
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