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AG017

Development stage: Unknown
Lead developer: Precigen ActoBio
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

AG017 is an investigational oral immunotherapy being developed by ActoBio Therapeutics, a subsidiary of Precigen. It is designed for the treatment of celiac disease. The drug consists of oral capsules containing a genetically engineered food-grade bacterium, *Lactococcus lactis*. This bacterium is modified to secrete a specific gliadin peptide along with an immunomodulating cytokine. The proposed mechanism of action is to induce antigen-specific immune tolerance to gliadin, a component of gluten, thereby addressing the underlying autoimmune cause of celiac disease. It is being studied in patients with the HLA-DQ2.5 genotype whose disease is well-controlled on a gluten-free diet.

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