AG1296

AG1296 (also known as Tyrphostin AG 1296) is a potent and selective small molecule inhibitor of the Platelet-Derived Growth Factor Receptor (PDGFR) tyrosine kinase. It belongs to the tyrphostin family of compounds and acts as an ATP-competitive inhibitor, blocking the autophosphorylation of both PDGFRα and PDGFRβ isoforms. Beyond PDGFR, AG1296 also demonstrates inhibitory activity against other related receptor tyrosine kinases, including FLT3 and c-Kit. In preclinical research, AG1296 is widely used as a tool to study the role of PDGF signaling in various cancers, particularly high-grade gliomas (HGG) and glioblastomas, where it has been shown to suppress cell proliferation and inhibit the induction of oncogenic long non-coding RNAs like LINC02283. While it is a valuable research reagent for investigating signal transduction and oncogenesis, AG1296 is not currently used as a clinical therapeutic agent.

Other names

6,7-Dimethoxy-2-phenylquinoxaline