Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Ag85B-ESAT-6
- Development stage
- Discontinued
- Lead developer
- Statens Serum Institut
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Intranasal
01
Overview
**Ag85B-ESAT-6** is a recombinant protein-subunit tuberculosis vaccine antigen, also called H1 or Hybrid-1, comprising a single fusion protein of the *Mycobacterium tuberculosis* antigens antigen 85B and early secretory antigenic target 6. It is designed to induce antigen-specific cellular immunity, particularly T-helper-1-associated responses, against *M. tuberculosis*. The antigen has been evaluated in Phase 1 studies in healthy adults as an unadjuvanted antigen and in distinct vaccine formulations with adjuvants including IC31, CAF01, and LTK63; those adjuvants are not part of the Ag85B-ESAT-6 fusion protein itself. Development of the H1 antigen was led by Statens Serum Institut for prevention of tuberculosis.
- Other names
- H1H-1H 1Hybrid-1Hybrid1Hybrid 1Ag85B-ESAT6Ag-85B-ESAT6Ag 85B-ESAT6
02
Targets
pMHC–TCR (Peptide–MHC–T-cell receptor complex)TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)
Beyond the preview
Go deeper on Ag85B-ESAT-6.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ag85B-ESAT-6.