Drug intelligence / Profile preview

agaricus bisporus

Development stage
Preclinical
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules, Recombinant Proteins and Enzymes, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral, Topical
01

Overview

Agaricus bisporus, commonly known as the white button mushroom when immature and white in color, is an edible basidiomycete fungus widely cultivated and consumed globally. It is the most familiar commercial mushroom and appears in various forms including brown (cremini) and mature (portobello). The fruiting body contains bioactive compounds such as polysaccharides (notably β-glucans), unsaturated fatty acids like linoleic acid and conjugated linoleic acid (CLA), arginine, benzoquinones, and vitamins. Pharmacological studies indicate immunostimulant effects via increased interferon-gamma production; anticancer activity through aromatase inhibition leading to reduced estrogen biosynthesis; hypolipidemic and antiglycemic effects by lowering plasma glucose and cholesterol levels; anti-inflammatory properties; antioxidant activity; enhancement of dendritic cell maturation; potential antibiotic properties due to benzoquinones; and cosmetic applications via tyrosinase enzyme content. Agaricus bisporus extracts have been studied for supportive roles in cancer prevention (especially breast cancer), type 2 diabetes management, hypercholesterolemia reduction, immune system modulation, liver protection support (with some caution regarding rare hepatotoxicity), cardiovascular health promotion, neuroprotection, stress reduction support, osteoporosis prevention support through vitamin D content after UV exposure[1][6][8][10].

Other names
white button mushroomcommon mushroombutton mushroomcultivated mushroomtable mushroomchampignon de Paris
02

Targets

CYP19A1 (Aromatase)

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