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agatolimod sodium + trastuzumab
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous, Intravenous
01
Overview
Agatolimod sodium is a synthetic 24-mer oligonucleotide containing three CpG motifs that selectively targets Toll-like receptor 9 (TLR9), activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens[5][7]. Trastuzumab is a monoclonal antibody targeting HER2/neu, which is overexpressed in certain breast cancers. The combination of agatolimod sodium with trastuzumab has been investigated as an immunotherapeutic approach to treat patients with locally advanced or metastatic breast cancer, aiming to enhance immune-mediated antitumor activity alongside direct HER2 inhibition[1][5].
- Other names
- agatolimod tricosasodium saltHerceptin (for trastuzumab, but not for the combination)CpG-7909 + trastuzumab
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)TLR9 (Toll-like receptor 9)
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