Drug intelligence / Profile preview

aged garlic extract

Development stage
Unknown
Lead developer
Wakunaga Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Aged garlic extract (AGE) is a dietary supplement produced by aging fresh garlic bulbs for at least 20 months at room temperature. This process converts unstable sulfur compounds in raw garlic, such as allicin, into more stable and bioavailable compounds like S-allylcysteine (SAC). AGE is claimed to have cardiovascular benefits including reducing blood pressure and arterial stiffness, improving cholesterol profiles, and exerting anti-inflammatory effects. Its mechanisms of action are thought to include stimulation of nitric oxide and hydrogen sulfide production leading to vasodilation, as well as inhibition of angiotensin-converting enzyme production. AGE also has antioxidant properties and may provide additional health benefits such as supporting immune function and reducing the risk of certain cancers. It is generally considered safe with fewer adverse effects than other forms of garlic supplements[1][4][5][8].

Brand names
Kyolic
Other names
AGEaged garlicgarlic extract
02

Targets

NOS1 (nNOS)ACE (Angiotensin Converting Enzyme)

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