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AGENT Drug-Coated Balloon
- Development stage
- Unknown
- Lead developer
- Boston Scientific
- Modality
- Small Molecules
- Administration
- Intracoronary
01
Overview
The **AGENT Drug-Coated Balloon (DCB)** is a monorail, semi-compliant percutaneous coronary intervention catheter developed as a drug-device combination. Its balloon surface is coated with **paclitaxel**, an antiproliferative chemotherapeutic agent, formulated in the proprietary **TransPax** coating, which includes the excipient acetyl tributyl citrate (ATBC)[1][3][5]. The device is used for **coronary angioplasty**, specifically to treat in-stent restenosis (ISR) in patients with coronary artery disease (CAD) whose coronary arteries have re-narrowed or become blocked following a previous stent insertion[1][6]. The balloon delivers a single, high-dose transfer of paclitaxel to the arterial wall, inhibiting neointimal proliferation and preventing further restenosis without leaving a permanent implant[1][4][5]. The AGENT DCB is the first and only coronary drug-coated balloon approved in the U.S. and provides an alternative to placing additional metal stents in previously stented coronary arteries[1][6].
- Brand names
- AGENT Drug-Coated BalloonAGENT DCBAGENT
- Other names
- AGENT Paclitaxel-Coated Balloon Catheter
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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