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Agent-F6
- Development stage
- Preclinical
- Lead developer
- MiNK Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**Agent-F6** is an investigational allogeneic invariant natural killer T cell chimeric antigen receptor therapy directed against B-cell maturation antigen. It was identified by MiNK Therapeutics using its CARDIS discovery platform as a BCMA-targeting CAR construct expressed in iNKT cells for off-the-shelf cell therapy. Preclinical data presented by the developer describe potent cytotoxicity against BCMA-expressing hematologic tumor cell lines and antitumor activity in a multiple myeloma xenograft model comparable to a clinical-stage BCMA CAR reference, supporting its development as a BCMA-directed cellular immunotherapy for plasma cell malignancies such as multiple myeloma.
- Other names
- BCMA CAR iNKT
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