Drug intelligence / Profile preview

ageratum conyzoides extract

Development stage
Unknown
Lead developer
Gencor
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ageratum conyzoides extract (ACE) is a standardized botanical extract derived from the annual herbaceous plant *Ageratum conyzoides*. Developed by Integrated Health Group Pty. Ltd., it is being investigated as an oral treatment for symptoms of benign prostatic hyperplasia (BPH). The extract's primary mechanism of action involves the inhibition of 5-alpha-reductase type 2, an enzyme critical for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, ACE suppresses androgen receptor signaling and downstream pathways that drive prostate cell proliferation and enlargement. Preclinical evidence suggests it improves prostate weight and epithelial thickness, while clinical studies have evaluated its efficacy in men with BPH symptoms.

Other names
Ageratum conyzoides extract
02

Targets

SRD5A2 (Steroid 5-alpha-reductase type II)

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