Drug intelligence / Profile preview

AglyMax

Development stage
Phase 3
Lead developer
Nichimo Biotics
Modality
Small Molecules, Peptides
Administration
Oral
01

Overview

AglyMax is a proprietary fermented soy isoflavone extract developed by Nichimo Co., Ltd. Unlike conventional soy extracts that primarily contain isoflavone glycosides, AglyMax is enriched with isoflavone aglycones—specifically daidzein, genistein, and glycitein—produced through a specialized fermentation process using *Aspergillus oryzae*. This fermentation improves the bioavailability of the isoflavones by removing the sugar moieties that otherwise hinder intestinal absorption. AglyMax is primarily investigated for its metabolic benefits, particularly its ability to improve insulin sensitivity and glucose metabolism in individuals with type 2 diabetes and metabolic syndrome. It also exhibits selective estrogen receptor modulator (SERM) activity, making it relevant for the management of menopausal symptoms and bone health. Additionally, the extract contains soy peptides produced during fermentation, which may contribute to its blood pressure-lowering and lipid-modulating effects.

Brand names
AglyMaxAgly-Max
Other names
Fermented soy isoflavone extractAglycone-rich soy isoflavone extractFermented soybean hypocotyl extract
02

Targets

ESR2 (ERβ)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)

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