Drug intelligence / Profile preview

agnimantha kwatha

Development stage
Phase 3
Lead developer
A & U Tibbia College Karol Bagh
Modality
Small Molecules
Administration
Oral
01

Overview

Agnimantha Kwatha is a traditional Ayurvedic herbal decoction prepared from the roots or bark of *Premna integrifolia* (syn. *Premna serratifolia*) or *Clerodendrum phlomidis*. It is a cornerstone formulation in Ayurvedic medicine, primarily indicated for the management of *Sthaulya* (obesity) and various inflammatory conditions. The preparation is characterized by its *Lekhana* (scraping) property, which is traditionally believed to facilitate the reduction of excess adipose tissue and the clearance of metabolic waste products. Pharmacologically, Agnimantha Kwatha exhibits anti-inflammatory, analgesic, anti-hyperlipidemic, and antioxidant activities. These therapeutic effects are attributed to a diverse phytochemical profile that includes alkaloids, flavonoids, and glycosides such as pectolinarin and premnazole. Beyond obesity, it is frequently employed in the treatment of lymphadenitis, diabetes mellitus, and urinary tract disorders.

Brand names
Agnimantha KashayamAgnimantha Kwath
Other names
Agnimantha KashayamAgnimantha DecoctionAgnimantha KwathPremna integrifolia decoction
02

Targets

Sucrase-IsomaltaseALOX12 (Arachidonate 12-lipoxygenase, 12S type)PNLIP (Pancreatic triacylglycerol lipase)COX

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