agonist anti-LTβR antibody

An agonist anti-LTβR antibody is a class of immunotherapeutic monoclonal antibodies designed to target and activate the lymphotoxin-beta receptor (LTβR), a member of the tumor necrosis factor receptor (TNFR) superfamily. LTβR signaling plays a critical role in lymphoid organogenesis, the development of high endothelial venules (HEVs), and the formation of tertiary lymphoid structures (TLS) within the tumor microenvironment. By mimicking the natural ligands (such as the membrane-bound LTα1β2 heterotrimer or LIGHT), these agonistic antibodies stimulate downstream classical and nonclassical NF-κB pathways. In oncology, this activation promotes the recruitment, education, and activation of T cells, B cells, and dendritic cells, potentially converting immunologically 'cold' tumors into 'hot' tumors. In transplantation and immunology research, LTβR agonism has also been investigated for its role in regulating lymphatic endothelial cell (LEC) phenotype and promoting regulatory T cell (Treg) migration to draining lymph nodes to enhance graft survival and immune tolerance.

Other names

agonist anti-LTbR Abagonist anti-LTbR antibodyagonist anti-LTβR Abagonist anti-LTβR antibodyanti-LTBR agonist antibodyanti-LTβR agonist antibodyLTBR agonist antibodyLTβR agonist antibodyLTβR agonist monoclonal antibody