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agrimoniae herba polysaccharides
- Development stage
- Preclinical
- Lead developer
- Beijing University of Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Agrimoniae herba polysaccharides (AHP) are active polysaccharide components extracted from *Agrimonia eupatoria* (Agrimoniae Herba), a traditional medicinal herb widely used in East Asia for treating intestinal inflammation. Developed by researchers at the Beijing University of Chinese Medicine, AHP is being investigated for the treatment of ulcerative colitis. Preclinical studies demonstrate that AHP remodels the gut microbiota, specifically enriching the abundance of *Faecalibaculum rodentium*. This enrichment leads to increased production of the metabolite quinic acid (QA), which subsequently drives CD4+ T cell differentiation toward regulatory T cells (Tregs) via the USP1/TAZ/Foxp3 axis, thereby alleviating intestinal inflammation and restoring immune homeostasis.
- Other names
- Agrimonia eupatoria polysaccharidesAgrimoniae Herba polysaccharideagrimony polysaccharides
02
Targets
IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)UCHL1 (Ubiquitin carboxyl-terminal hydrolase 1)
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