Drug intelligence / Profile preview

agrostis gigantea pollen allergen extract

Development stage
Unknown
Lead developer
ALK Abelló
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intradermal, Sublingual, Oral
01

Overview

Agrostis gigantea pollen allergen extract, also known as Redtop grass pollen extract, is a biological product used for the diagnosis and treatment of Type I hypersensitivity reactions (allergies) to this specific grass. [17, 11] It is administered for diagnostic purposes via skin prick or intradermal tests to confirm sensitivity. [3, 4] For therapeutic use, it is a key component of allergen immunotherapy, available as subcutaneous injections (allergy shots) or sublingual drops/tablets. [10, 16] The goal of immunotherapy is to induce immune tolerance by gradually exposing the body to increasing doses of the allergen. [16] This process modulates the immune response, shifting it from a pro-allergic Th2-dominant profile to a more tolerant state, characterized by the production of blocking IgG antibodies and a reduction in allergen-specific IgE levels, thereby alleviating symptoms of allergic rhinitis (hay fever), allergic conjunctivitis, and allergic asthma upon natural exposure. [12, 16]

Brand names
Redtop Grass Pollen Extract
Other names
Redtop grass pollen extractAgrostis alba pollen extract
02

Targets

High-affinity immunoglobulin epsilon receptor-bound Immunoglobulin E complexIgE (Immunoglobulin E)sIgG4 (Allergen-specific immunoglobulin G4)

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