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AGS-8M4 + carboplatin + gemcitabine
- Development stage
- Discontinued
- Lead developer
- Astellas Pharma
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
AGS-8M4 + carboplatin + gemcitabine is an investigational combination regimen, with AGS-8M4 (also referred to as ASP6183) being a human monoclonal antibody, typically considered for use with established chemotherapy drugs carboplatin and gemcitabine. AGS-8M4 is an anti-cancer antibody studied for safety, pharmacokinetics, immunogenicity, and anti-tumor activity, while carboplatin (a platinum analog) and gemcitabine (a nucleoside analog) are used together to inhibit DNA synthesis and cell division in cancer cells. The combination is used or explored as a treatment for several cancers, including advanced solid tumors and ovarian cancer.
- Brand names
- GemCarbo
- Other names
- gemcitabine and carboplatingemcitabine plus carboplatin
02
Targets
DNARNR (Ribonucleotide reductase)
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