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AGT-NeoPrime DC
- Development stage
- Preclinical
- Lead developer
- AngenMed
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Parenteral
01
Overview
AGT-NeoPrime DC is a personalized dendritic cell (DC)-based cancer immunotherapy developed by AngenMed Therapeutics as part of the AGT-NeoSync platform. The therapy involves isolating a patient's own dendritic cells and educating them using a custom-synthesized tumor neoantigen (NeoAg) mRNA vaccine, which is designed based on whole-genome sequencing of the patient's tumor. These neoantigen-loaded dendritic cells function as antigen-presenting cells to activate and expand neoantigen-specific antitumor T-cell responses. It is intended for the treatment of various solid tumors and is typically used in conjunction with AGT-NeoBoost T-cells.
- Brand names
- NeoPrime DC
- Other names
- AGT-NeoPrime® DC
02
Targets
pMHC (Peptide-MHC complex family)
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