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Ailamide
- Development stage
- Phase 4
- Lead developer
- Senju Pharmaceutical
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
**Ailamide** is a Japanese fixed-dose ophthalmic suspension containing brimonidine tartrate 0.1% and brinzolamide 1%. It is marketed for reducing elevated intraocular pressure in glaucoma and ocular hypertension when other glaucoma therapies provide insufficient control. Brimonidine is an alpha-2 adrenergic receptor agonist that reduces aqueous-humor production and promotes uveoscleral outflow, while brinzolamide inhibits carbonic anhydrase II to reduce aqueous-humor secretion. The product was approved in Japan in March 2020 and launched in June 2020 by Senju Pharmaceutical with Otsuka Pharmaceutical as its alliance partner. ([otsuka.co.jp](https://www.otsuka.co.jp/en/company/newsreleases/2020/20200616_1.html))
- Brand names
- Ailamide
- Other names
- 0.1% brimonidine tartrate + 1% brinzolamide fixed-combination ophthalmic suspensionAILAMIDE Combination Ophthalmic Suspensionアイラミド配合懸濁性点眼液
02
Targets
ADRA2B (α2B)ADRA2C (α2C)CA2 (Carbonic Anhydrase 2)ADRA2A (α2A)
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