AJ206

AJ206 is a first-in-class bicyclic peptide-based PET radiotracer designed for the non-invasive quantification of CD38 expression. Developed by researchers at Johns Hopkins University, AJ206 exhibits high affinity (KD ~19 nM) for human CD38, a receptor highly expressed in multiple myeloma (MM). When labeled with Gallium-68 ([68Ga]AJ206), it allows for the evaluation of CD38 pharmacodynamics and therapy response (e.g., following ATRA treatment) in MM lesions that are difficult to assess via routine blood testing. The tracer demonstrates rapid clearance from normal tissues and high tumor-to-muscle ratios, providing high-contrast PET imaging in preclinical models.

Other names

[68Ga]AJ206