ajmaline

Ajmaline is a class Ia antiarrhythmic alkaloid derived from the root of Rauwolfia serpentina and other plant sources. It is primarily used to manage various forms of tachycardias, including atrial fibrillation in patients with Wolff–Parkinson–White syndrome and well-tolerated monomorphic ventricular tachycardias. Ajmaline is also widely used as a diagnostic agent to unmask the type-1 Brugada syndrome electrocardiogram pattern. Its mechanism of action involves blocking sodium channels (notably the Nav 1.5 channel), which lengthens cardiac action potentials and slows conduction velocity, thereby stabilizing abnormal heart rhythms. Ajmaline also has additional effects on potassium (including hERG) and calcium channels, further prolonging repolarization and refractory periods[1][2][3][6].

Brand names

Gilurytmal