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AK0707
- Development stage
- Phase 1
- Lead developer
- Ark Biosciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
AK0707 is an orally bioavailable small-molecule inhibitor of Rho-associated protein kinase 2 (ROCK2), currently under development by ArkBiopharmaceutical (Suzhou 爱科百发生物医药技术有限公司) for the treatment of idiopathic pulmonary fibrosis (IPF). ROCK2 is a serine/threonine kinase that regulates various cellular processes, including cytoskeletal organization, cell migration, and gene expression, and is a key mediator in the pathogenesis of fibrotic diseases. By selectively inhibiting ROCK2, AK0707 aims to suppress the pro-fibrotic signaling pathways that lead to myofibroblast differentiation and excessive collagen deposition in the lungs. The compound has been evaluated in Phase 1 clinical trials to assess its safety, tolerability, and pharmacokinetics in healthy volunteers.
02
Targets
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2)ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
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