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AK104 + AK117 + capecitabine + oxaliplatin
- Development stage
- Phase 2
- Lead developer
- Kangfang Sainuo Pharmaceutical
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination is an investigational therapeutic regimen comprising four agents for oncology use, primarily in advanced or metastatic solid tumors such as gastric or gastroesophageal junction (GEJ) adenocarcinoma. **AK104 (cadonilimab)** is a bispecific monoclonal antibody targeting both PD-1 and CTLA-4, acting as an immune checkpoint inhibitor to enhance antitumor immunity. **AK117 (ligufalimab)** is a humanized IgG4 monoclonal antibody targeting CD47, blocking the CD47-SIRPα interaction to promote macrophage-mediated phagocytosis of tumor cells without causing hemagglutination. **Capecitabine** is an oral prodrug of 5-fluorouracil (5-FU), inhibiting DNA synthesis as an antimetabolite. **Oxaliplatin** is a platinum-based chemotherapeutic causing DNA crosslinking and apoptosis. Clinical trials of this four-drug combination have reported favorable safety and early efficacy signals in patients with advanced HER2-negative gastric and GEJ cancers[2][4]. AK104 and AK117 are both developed by Akeso.
- Other names
- cadonilimab + ligufalimab + capecitabine + oxaliplatin
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)DNAPDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)CD47 (Cluster of Differentiation 47)
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