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AK105 + anlotinib + capecitabine + oxaliplatin
- Development stage
- Phase 2
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination consists of four anticancer agents: - **AK105** is an anti-PD-1 monoclonal antibody (immune checkpoint inhibitor) designed to block programmed death-1 (PD-1) pathway, enhancing T cell-mediated immune responses against tumors. - **Anlotinib** is an oral multi-targeted tyrosine kinase inhibitor that affects angiogenesis and tumor cell proliferation by inhibiting vascular endothelial growth factor receptors (VEGFR1/2/3), platelet-derived growth factor receptors (PDGFRα/β), fibroblast growth factor receptors (FGFR1-4), c-Kit, and MET[1][3][5]. - **Capecitabine** is an oral prodrug of 5-fluorouracil (5-FU), a cytotoxic antimetabolite interfering with DNA synthesis in rapidly dividing cells[2][6]. - **Oxaliplatin** is a platinum-based chemotherapeutic agent that forms DNA crosslinks, leading to apoptosis of cancer cells[2][6]. The combination brings together immunotherapy (AK105), anti-angiogenic targeted therapy (anlotinib), and cytotoxic chemotherapy (capecitabine, oxaliplatin) for synergistic antitumor effects. It is under clinical investigation for treatment of various advanced malignancies, most notably colorectal cancer and other gastrointestinal tumors.
- Brand names
- XELOXCAPOX
- Other names
- AK105 + anlotinib + capecitabine + oxaliplatin
02
Targets
DNAFGFR2 (Keratinocyte growth factor receptor)PDCD1 (Programmed cell death protein 1 receptor)PDGFRB (Platelet-derived growth factor receptor beta)TS (Thymidylate synthase)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR1 (Fibroblast growth factor receptor 1)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)MET (Mesenchymal-epithelial transition factor receptor)PDGFRA (Platelet-derived growth factor receptor alpha)VEGFR-1 (Vascular endothelial growth factor receptor 1)
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