akebia quinata saponins

**Akebia quinata saponins** are triterpenoidal saponins isolated from the fruits and stems of *Akebia quinata*, a plant used in Traditional Chinese Medicine for antiphlogistic and urinary tract inflammatory conditions. These saponins, including **akebia saponin PA**, **hederacoside C**, and **hederacolchiside F**, exhibit bioactivities such as enhancing glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, with akebia saponin PA showing strong effects comparable to gliclazide in INS-1 cells via pathways involving PDX-1 overexpression, ERK1/2, IRS-2, PI3K, and Akt. They also demonstrate antinociceptive, anti-inflammatory properties, and antioxidant activity, attributed partly to hydrolysis into sapogenins like hederagenin and oleanolic acid.[1][2][3][5]

Other names

akebia saponin PAhederacoside Chederacolchiside Fkalopanaxsaponin A